Status:
UNKNOWN
Myeloproliferative Neoplasms and Bone Structure
Lead Sponsor:
University of Southern Denmark
Conditions:
Polycythemia Vera
Thrombocythemia, Essential
Eligibility:
All Genders
18+ years
Brief Summary
This is a clinical study to evaluate the effect of CMPN (Chronic myeloproliferative neoplasm) to the bone. The hypothesis is that patients with CMPN have a higher fracture-rate compared to the backgr...
Detailed Description
This is a clinical study to evaluate the effect of CMPN to the bone. Three individual cohorts are defined; a cohort consisting of 50 patients with Polycythemia Vera (PV), a cohort consisting of 50 pa...
Eligibility Criteria
Inclusion
- Diagnosis of PV (according to WHO 2008 criteria), only JAK2-pos.(Janus kinase 2)
- Diagnosis of ET (according to WHO 2008 criteria), only JAK2-pos.
- Diagnosis of PMF (according to WHO 2008 criteria)independent of JAK2-status.
Exclusion
- Pregnancy
- Bone Diseases (Mb. Pagets, Myelomatosis, MGUS (monoclonal gammopathy of undetermined significance), osteogenesis imperfecta, Prim. hyperparathyroidism, osteomalacia.
- Drugs (Prednisone\>3 mth, anti-osteoporotic drugs, anti-estrogen drugs.
- Presence of any psychologic condition or language barrier, which may interfere which a complete understanding, and arise ethnical considerations.
Key Trial Info
Start Date :
March 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2015
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT01816022
Start Date
March 1 2012
End Date
March 1 2015
Last Update
March 21 2013
Active Locations (1)
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1
Faculty of Health Sciences, Institute of Clinical Research
Odense, Region Syddanmark, Denmark, 5000