Status:
COMPLETED
The Effect of Exercise on Strength and Mobility and Corresponding CNS Plasticity in Multiple Sclerosis Patients
Lead Sponsor:
University of Nebraska
Collaborating Sponsors:
Biogen
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
19-65 years
Phase:
NA
Brief Summary
This study is a unique blend of new technologies never used in combination with individuals diagnosed with Multiple Sclerosis (MS). The results of this research will define changes in brain activity, ...
Detailed Description
Rationale MEG is a direct measure of ongoing neurophysiological activity and is appropriate because of spatiotemporal resolution of measurements and immunity of the technique to vascular biases that c...
Eligibility Criteria
Inclusion
- A diagnosis of relapsing/remitting or secondary progressive MS by McDonald Criteria (for patient groups)
- Competent to give informed consent.
- ≥ 19 years and \<65 years of age.
- EDSS score \<7.0 and able to walk 25 feet with or without a cane.
- Willingness to comply with the evaluation schedule for the study. This includes participation in a bi-weekly standardized structured resistance training and separate data collections done at each time point (baseline and 3 months).
- Evidence that the MS patient's physical and neurological examinations are "clinically acceptable." Clinically acceptable is defined as those clinical findings or conditions that would not place the patient in undue risk by participating and which would not interfere with outcome measures of the study.
Exclusion
- Unable to give informed consent.
- Unable or unwilling to sign safety waiver.
- EDSS score ≥7 or are unable to walk 25 feet with the use of a cane
- Unwilling or unable to complete the exercise program and other aspects of the study (e.g., not keeping appointments, lack of active participation in the exercise sessions, or displaying inability to follow instructions allowing appropriate exercise advancement).
- Pregnant, breastfeeding or within 3 months post partum at initiation of study.
- Have any other disability that would affect balance and/or mobility.
- Have any other neurological or neurodegenerative disorders.
- Have any other conditions, clinical findings or reason that deems the subject unsuitable for enrollment into the study.
- Have an implantable device or history of metal in body.
Key Trial Info
Start Date :
September 16 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT01816100
Start Date
September 16 2013
End Date
September 1 2015
Last Update
September 1 2023
Active Locations (1)
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1
Unversity of Nebraska Medical Center
Omaha, Nebraska, United States, 68198