Status:
UNKNOWN
The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose
Lead Sponsor:
Taipei Veterans General Hospital, Taiwan
Conditions:
Diabetes
Eligibility:
All Genders
35-70 years
Phase:
PHASE4
Brief Summary
Evaluate the effects of rosuvastatin (maybe the highest diabetogenic) and pravastatin (seems to be protective) on the glucose homeostasis and other biomarkers in subjects with impaired fasting glucose...
Detailed Description
Statin therapy effectively reduces cardiovascular events. However, trial data1 and meta-analyses suggest that statins also confer increased risk of development of diabetes. In order to elucidate wheth...
Eligibility Criteria
Inclusion
- Age 35-70 years old
- Fasting blood glucose 100-125 mg/dL
Exclusion
- A1C \>7.0%
- 2hr glucose during OGTT \>200 mg/dL
- Total cholesterol \>280 mg/dL
- Previous diabetic history, coronary artery disease
- Allergy to rosuvastatin or parvastatin
- Baseline ALT more than 3 times UNL
- Serum Cr \> 2.0 mg/dL
- Pregnancy, breast feeding or plan to be pregnant woman.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT01816997
Start Date
January 1 2012
End Date
December 1 2022
Last Update
November 18 2013
Active Locations (1)
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1
Taipei Veterans General Hospital
Taipei, Taipei, Taiwan, 11217