Status:
UNKNOWN
Chronic Remote Ischemic Conditioning to Modify Post-MI Remodeling
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
University Health Network, Toronto
Sunnybrook Health Sciences Centre
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
During a heart attack, an artery carrying blood and oxygen to the heart becomes blocked, which causes damage to the heart muscle. When possible, a clot-busting drug is given or a procedure called angi...
Eligibility Criteria
Inclusion
- (i) Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes; (ii) Antegrade TIMI 0 or 1 prior to PCI; (iii) Age ≥18 years; (iv) Informed consent from patient or next of kin.
Exclusion
- (i) Known history of diabetes; (ii) Coronary anatomy warranting emergent coronary artery bypass graft surgery; (iii) Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation); (iv) Need for hemodialysis; (v) Malignancy, HIV, or central nervous system disorder; (vi) Cardiopulmonary resuscitation \>15 min and compromised level of consciousness; (vii) Cardiogenic shock; (viii) Current participation in any research study involving investigational drugs or devices; (ix) Inability to safely undergo cMRI
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01817114
Start Date
March 1 2013
End Date
March 1 2017
Last Update
July 15 2016
Active Locations (3)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
2
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
3
University Health Network, Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4