Status:
WITHDRAWN
A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)
Lead Sponsor:
Yonsei University
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
20-75 years
Phase:
NA
Brief Summary
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
Eligibility Criteria
Inclusion
- dyspnea at rest or minimal activity
- tachypnea (respiratory rate \> 20/min) or rales or pulmonary edema on chest X-ray
- who need diuretics add over 40mg of daily furosemide dose
Exclusion
- Hospitalization for acute heart failure decompensation
- cardiogenic shock (Systolic Blood Pressure \< 80mmHg)
- Need or plan for renal replacement therapy (dialysis, kidney transplant)
- serum creatine level \> 2.5mg/dl
- serum potassium (K+) \> 5.5mg/dl
- daily spironolactone dose \> 50mg
- previous thiazide or metolazone user
- Age \> 75 years old or poor compliance patients 9. allergy, adverse drug reaction, hypersensitivity to any kinds of diuretics 10. life expectancy \< 6 months (e.g. metastatic malignancy, liver cirrhosis) 11. pregnancy or women at age of childbearing potential
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01817803
Start Date
March 1 2013
End Date
December 1 2015
Last Update
February 19 2014
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