Status:
COMPLETED
Residual Platelet Activity Despite Aspirin Utilization in Coronary Heart Disease
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conditions:
Coronary Heart Disease
Non ST-elevation Acute Coronary Syndromes
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to compare the response to aspirin in the acute phase with the late phase of an acute coronary syndrome.
Detailed Description
The purpose of this study is to compare, in the same population, the response to aspirin in the initial phase (first 48 hours) with the late phase (after 3 months of discharge)of a non ST elevation ac...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Confirmed diagnosis of acute coronary syndrome without ST segment elevation, in the first 48 hours after the onset of the clinical symptoms
- Regular use of aspirin for at least seven days.
Exclusion
- Previous use, in the last 7 days, of another antiplatelet agent than aspirin
- Use of antivitamin K in the last 3 weeks
- Hemoglobin \< 10g/dL and / or hematocrit \< 30% or \> 50%, platelets count \< 100.000/mm3 or \> 500.000/mm3, creatinine clearance \< 30 mL / minute
- Killip class III or IV
- Need for vasopressor or inotropic parenteral medication at inclusion in the study
- Percutaneous coronary intervention within 30 days or CABG in the last 90 days prior to study entry
- Current malignancy
- Hematologic diseases
- Refusal to sign the inform consent form
- Unable to attend the second visit (follow-up) for any reason except for death
Key Trial Info
Start Date :
December 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01820429
Start Date
December 1 2009
End Date
April 1 2012
Last Update
March 28 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Instituto do Coração (Heart Institute) - Clinical Hospitals, University of São Paulo Medical School
São Paulo, São Paulo, Brazil, 05403900