Status:
TERMINATED
Extubation Failure Prevention in High Risk Patients by High-flow Conditioned Oxygen Therapy vs. Standard Oxygen Therapy
Lead Sponsor:
Althaia Xarxa Assistencial Universitària de Manresa
Conditions:
Respiratory Failure
Eligibility:
All Genders
18-95 years
Phase:
NA
Brief Summary
Failure of extubation after mechanical ventilation is a frequent and deleterious issue. Main reasons for failure are hypoxemia, secretions retention, lung collapse and excessive work of breathing. Mos...
Eligibility Criteria
Inclusion
- Patients mechanically ventilated for \> 48 hours and at least one of the following:
- \>65 years
- cardiac failure as the primary indication of mechanical ventilation
- Chronic Obstructive Pulmonary Disease
- Severity score (APACHE II \>12 points) the extubation day
- Body Mass Index \>30
- inability to manage respiratory secretions
- 1 failed spontaneous breathing trial
- 1 comorbidity
- 7 days under mechanical ventilation
Exclusion
- \<18 years
- tracheotomized patients
- recent facial or cervical trauma/surgery
- active gastro-intestinal bleeding
- lack of cooperation
- patients with any failed spontaneous breathing trial because of hypercapnia development.
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
155 Patients enrolled
Trial Details
Trial ID
NCT01820507
Start Date
March 1 2013
End Date
January 1 2015
Last Update
January 30 2015
Active Locations (1)
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1
ICU. Fundacio Althaia
Manresa, Barcelona, Spain, 08242