Status:
COMPLETED
Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
Aarhus University Hospital
Conditions:
Preeclampsia
Type 1 Diabetes
Eligibility:
FEMALE
18-45 years
Brief Summary
A tonic active epithelial Na+ channel (ENaC) in pre-eclampsia (PE) escaped normal hormonal control may offer an attractive explanatory model for the pathophysiology of established PE. The channel is a...
Detailed Description
Study aim and hypothesis: Aim: To test whether there is a measurable correlation between plasmin/plasminogen, abnormally excreted in the kidneys, and the development of pre-eclampsia in pregnant wom...
Eligibility Criteria
Inclusion
- singleton gravida,
- over 18 years,
- Pregestational type 1 diabetes. Gestation week 8-14.
Exclusion
- Possible comorbidity like systemic lupus erythematosus (SLE), hypertension and rheumatoid arthritis.
- Organic or systematic diseases with clinical relevance ( ex. Malignity)
- However it has to be mentioned that quite some patients have thyroid diseases with no impact on the kidneys nor hypertension. It is therefore possible to include these patients.
- Thyroid diseases are NOT a reason for exclusion.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT01821053
Start Date
June 1 2013
End Date
October 1 2015
Last Update
October 16 2015
Active Locations (1)
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1
Gynelogical Obstetrical Department
Skejby, Aarhus N, Denmark, 8200