Status:
COMPLETED
Paracetamol CSF Pharmacokinetics Study
Lead Sponsor:
Barts & The London NHS Trust
Conditions:
Paracetamol
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Despite its use for decades all over the world, the exact mechanism of action of paracetamol is not fully understood and essentially involves a combination of hypotheses. It is known to have an effect...
Detailed Description
Patients undergoing spinal blockade for urological surgery were administered 1g paracetamol intravenously at varying intervals prior to spinal anaesthesia, at which time 5mls of cerebrospinal fluid an...
Eligibility Criteria
Inclusion
- Adult subjects aged 18 to 80 years
- Subjects undergoing surgery who require a spinal anaesthetic and paracetamol as part of their routine anaesthetic plan
- Subjects with an American Society of Anesthesiology score of I-III
Exclusion
- Subjects with any contraindication to spinal anaesthesia
- Subjects with known clotting abnormalities
- Pregnant or lactating women
- Subjects with known hypersensitivity to paracetamol
- Patients with severe hepatocellular insufficiency
- Patients already taking regular doses of paracetamol
- Any subjects deemed medically unsuitable by the investigator
Key Trial Info
Start Date :
May 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2011
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01821872
Start Date
May 1 2011
End Date
November 1 2011
Last Update
April 4 2013
Active Locations (1)
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1
St Bartholomew's Hospital
London, United Kingdom, EC1A