Status:
WITHDRAWN
Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function
Lead Sponsor:
Creighton University
Conditions:
Hypertension
Eligibility:
All Genders
19+ years
Phase:
PHASE4
Brief Summary
Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.
Detailed Description
This is a randomized, double-blind, crossover study to evaluate chlorthalidone and hydrochlorothiazide and their effects on endothelial function in hypertensive patients. Subjects will receive chlorth...
Eligibility Criteria
Inclusion
- Age 19 or older
- Diagnosis of hypertension
- Current blood pressure \> 120/80 mm Hg
Exclusion
- Use of a thiazide-type diuretic within the last 1 month
- Known allergy to any study medications
- History of gout or hyperuricemia
- SCr \>/= 1.8 mg/dl or CrCl \< 25 ml/min
- Pregnancy or breastfeeding or planning to become pregnant during study period
- Dementia or cognitive impairment
- Hypokalemia
- Acute coronary syndrome or stroke within 6 months
- Current use of sildenafil, tadalafil, or vardenafil
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01822860
Start Date
March 1 2013
End Date
February 1 2015
Last Update
March 25 2015
Active Locations (1)
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1
Creighton University
Omaha, Nebraska, United States, 68131