Status:
UNKNOWN
Effect of Plant Sterol Enriched Milk on Plasma Lipid Levels of Humans Breast-fed During Infancy
Lead Sponsor:
University of Manitoba
Conditions:
Hypercholesterolemia
CVD
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The overall goal of this clinical study is to investigate how dietary cholesterol intake influences the plasma Total cholesterol (TC), LDL-Cholesterol levels and cholesterol metabolism between adults ...
Detailed Description
Hypothesis 1: To determine the responsiveness of plasma lipid profile including Total cholesterol and LDL cholesterol concentrations to high and low cholesterol diets in adults who been breast-fed as ...
Eligibility Criteria
Inclusion
- Triglycerides (TG) \<3.0 mmol/L
- Body mass index (BMI) between 20 and 30 kg/m2
- Participants must have been breast-fed at least during the first 6 months of their life
Exclusion
- History of recent (i.e. less than 1 month) or chronic use of oral hypolipidemic therapy, including fish oils, or probucol within the last 3 months
- History of chronic use of alcohol (\>2 drinks/d), smoking, systemic antibodies, corticosteroids, androgens, or phenytoin
- Myocardial infarction, coronary artery bypass, kidney disease, liver disease or other major surgical procedures within the last six months,
- Sitosterolemic patients
- Recent onset of angina, congestive heart failure, inflammatory bowel disease, pancreatitis, diabetes, or significant current (i.e. onset within past three months) gastrointestinal, renal, pulmonary, hepatic or biliary disease, or cancer (evidence of active lesions, chemotherapy or surgery in the past year)
- Exercise greater than walking or running 15 miles/wk or 4,000 kcal/wk
- Participants who have not been breast-fed at all
- Pregnant or planning for pregnancy during the next 5 month period
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT01825668
Start Date
March 1 2013
End Date
June 1 2016
Last Update
February 3 2016
Active Locations (1)
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1
Richardson Centre for Functional Foods and Nutraceuticals
Winnipeg, Manitoba, Canada, R3T 2N2