Status:
COMPLETED
Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock
Lead Sponsor:
Helsinki University Central Hospital
Conditions:
Septic Shock
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The aim of the study is to evaluate whether fluid responsiveness of the critically ill patient can be assessed by analysing the PEEP-induced hemodynamic effects to systolic blood pressure, pulse press...
Eligibility Criteria
Inclusion
- • Written informed consent by patient or relative
- Time in ICU \< 48 hours
- Septic shock
- Pulmonary artery catheter and radial arterial catheter
- Age 18 - 75 years
- Sinus rhythm
- Need for norepinephrine over 0.1 ug/kg/min but otherwise hemodynamically stable i.e no need to change the dose over the last 15min period before the study
- Mechanical ventilation with sedation
- Pwcp \<18 mmHg
Exclusion
- Contraindication to elevation of PEEP ( elevated intracranial pressure, pulmonary hypertension or other contraindication )
- Contraindication to fluid challenge
- Contraindication to TEE
- Previous heart failure, heart valve stenosis of insufficiency
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01827007
Start Date
January 1 2008
End Date
February 1 2013
Last Update
April 9 2013
Active Locations (1)
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1
Intensive Care Unit 20, Meilahti Hospital
Helsinki, HUS, Finland, 00029