Status:
COMPLETED
Acute and Chronic Nicotine Modulation of Reinforcement Learning
Lead Sponsor:
Duke University
Conditions:
Nicotine Addiction
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural a...
Eligibility Criteria
Inclusion
- Inclusion criteria for all subjects:
- generally healthy
- between the ages of 18-55
- right-handed
- Inclusion criteria for nonsmokers:
- smoked \< 50 cigarettes of a brand delivering ≥ 0.5 mg nicotine (FTC method)
- have not smoked in ≥ 6 months
- afternoon expired CO concentration ≤ 5 ppm and/or morning urinary NicAlert \< 100 ng/ml
- Inclusion criteria for smokers
- smoke ≥ 10 cigarettes/day of a brand delivering ≥ 0.5 mg nicotine (FTC method)
- smoked ≥ 2 years
- afternoon expired CO concentrations ≥ 10 ppm and/or morning urinary NicAlert \> 100 ng/ml
Exclusion
- inability to attend all required experimental sessions
- significant health problems (e.g., current and uncontrolled liver, lung, or heart problems, current or past seizure disorder, serious head trauma)
- lifetime diagnosis of Axis I psychiatric disorders (e.g., depression, anxiety disorder, schizophrenia)
- meet DSM-V criteria for past or current substance dependence other than nicotine
- use of psychoactive medications as indicated by self-report
- use of smokeless tobacco, nicotine replacement therapy, or desire to change smoking behavior while in the study
- positive urine drug screen for illicit drugs or positive breath alcohol concentration
- presence of conditions that would make MRI unsafe
- having vision that cannot be corrected to 20/40
- among women, nursing or a positive pregnancy test
- inability to achieve learning criteria in training session
Key Trial Info
Start Date :
February 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2016
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01830842
Start Date
February 1 2014
End Date
August 31 2016
Last Update
December 19 2017
Active Locations (1)
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1
Duke University
Durham, North Carolina, United States, 27705