Status:
COMPLETED
Correlates and Consequences of Increased Immune Activation in Injection Drug Users
Lead Sponsor:
Rockefeller University
Conditions:
Intravenous Drug Usage
Eligibility:
All Genders
18-55 years
Brief Summary
The goal of this study is to learn how injection drug use may affect the immune system.
Detailed Description
The goal of this study is to learn how injection drug use may affect the immune system. One way to measure this is by looking at the blood and the gut, or gastrointestinal tract at the same time. It i...
Eligibility Criteria
Inclusion
- Ability to give informed consent
- Between the ages of 18 and 55
- Absence of medical conditions that would preclude flexible sigmoidoscopy
- Absence of active opportunistic infection requiring active therapy including antibiotics or anti-neoplastics (note this does not include prophylactic antibiotic therapy)
Exclusion
- History of bleeding disorder
- Platelet count below 70,000
- INR\>1.5 or PTT\>2X control
- Active use of anticoagulants or aspirin therapy that cannot be interrupted
- Comorbid diagnosis of inflammatory bowel disease
- Pregnancy, incarceration, mentally disabled individuals
- HIV-1 infection
- Currently on Hepatitis C treatment
Key Trial Info
Start Date :
December 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
201 Patients enrolled
Trial Details
Trial ID
NCT01831284
Start Date
December 1 2012
End Date
September 1 2014
Last Update
November 6 2014
Active Locations (1)
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1
The Rockfeller University
New York, New York, United States, 10065