Status:
COMPLETED
Myeloproliferative Neoplasms: an In-depth Case-control Study
Lead Sponsor:
Queen's University, Belfast
Collaborating Sponsors:
University Hospital Southampton NHS Foundation Trust
University of Manchester
Conditions:
Polycythemia Vera
Essential Thrombocythemia
Eligibility:
All Genders
18+ years
Brief Summary
There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control s...
Detailed Description
MPNs are a group of haematopoietic malignancies resulting from a transformed haematopietic progenitor cell. They are characterised by overproduction of mature functional blood cells. MPNs were histori...
Eligibility Criteria
Inclusion
- Myeloproliferative neoplasm cases
- Inclusion criteria:
- Clinical diagnosis of polycythemia vera, essential thrombocythaemia or primary myelofibrosis based on the WHO diagnostic criteria.
- Aged 18 years or older.
Exclusion
- younger than 18 years old.
- where the clinician/General Practitioner (GP) does not provide consent.
- incapable of giving informed consent.
- physically or cognitively incapable of completing the questionnaire.
- too ill to participate
- General Practice Controls
- Inclusion Criteria:
- Randomly selected, frequency matched to the distribution of cases by 5-year age band, geographic location (Belfast and Southampton) and gender.
- Aged 18 years or older.
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT01831635
Start Date
April 1 2013
End Date
June 1 2015
Last Update
January 8 2024
Active Locations (3)
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1
University Hospitals Southampton NHS Foundation Trust
Southampton, England, United Kingdom, SO16 6YD
2
Belfast Health And Social Care Trust
Belfast, Northern Ireland, United Kingdom, BT12 6BJ
3
Queen's University Belfast
Belfast, Northern Ireland, United Kingdom, BT389EX