Status:
COMPLETED
89Zr-MMOT PET Imaging in Pancreatic and Ovarian Cancer Patients
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
Amsterdam UMC, location VUmc
Genentech, Inc.
Conditions:
Ovarian Neoplasms
Ovarian Diseases
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this multicenter imaging sub study is to evaluate the biodistribution and organ pharmacokinetics of 89Zr-MMOT0530A in patients with unresectable pancreatic or platinum-resistant ovarian...
Detailed Description
A challenge in current drug development using molecular targeted therapies is the high level of heterogeneity that is present in specific tumor types. The ability to safely and accurately predict the ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Adult patients, \>/= 18 years of age
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Histologically documented, incurable, locally advanced or metastatic disease for which no standard therapy exists, consisting of one of the following: Unresectable pancreatic ductal adenocarcinoma or platinum-resistant ovarian cancer
- Measureable disease, defined as at least one bi-dimensionally measurable non-lymph node lesion \>/= 1 cm in long-axis diameter on spiral CT scan or at least one bi-dimensionally measurable lymph node measuring \>/= 1.5 cm in short-axis diameter on spiral CT scan
- Adequate hematological, renal and liver function
- Exclusion criteria:
- Treatment with anti-tumor therapy, including chemotherapy, biologic, experimental or hormonal therapy, within 4 weeks prior to Day 1
- Known active infection
- Current Grade \>/= 2 toxicity (except for alopecia, anorexia and fatigue) from prior therapy or Grade \>/= 2 neuropathy
- Untreated or active cerebral nervous system (CNS) metastases
- Pregnant or breastfeeding women
Exclusion
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT01832116
Start Date
March 1 2013
End Date
May 1 2014
Last Update
May 3 2024
Active Locations (2)
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1
VU Medical Center
Amsterdam, Netherlands, 1081HV
2
University Medical Center Groningen
Groningen, Netherlands, 9713GZ