Status:
ENROLLING_BY_INVITATION
Molecular Basis of Food Allergy
Lead Sponsor:
Children's Hospital of Philadelphia
Collaborating Sponsors:
University of Pennsylvania
Children's Hospital Medical Center, Cincinnati
Conditions:
Food Allergy
Eosinophilic Esophagitis
Eligibility:
All Genders
1-65 years
Brief Summary
The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells, basophils and cytokines in the development of food allergy. The study also explores the...
Detailed Description
Food Allergy (FA) is a common pediatric atopic disease. Characteristically children affected by FA become sensitized to food in the first few months of life and spontaneously outgrow the disease by 5-...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Study Group:
- Males or females age 1 month to 65 years.
- Diagnosis of Food Allergy. Food Allergy can be either IgE or non-IgE mediated food allergy including Eosinophilic Esophagitis and Food Protein Induced Enterocolitis.
- Inclusion Criteria for Control group:
- Age and sex matched patients without food allergies
- Sibling and parents of patients with food allergies
- Inclusion Criteria for Control group with atopy:
- Age and sex matched patients without food allergies
- Sibling and parents of patients with food allergies
- Patients with atopy
- Exclusion Criteria
- Underlying disease or medical problem that is judged to serious or risky to allow 3 ml/kg of blood to be drawn from a vein (such as serious anemia, cancer, poor vein abscess, serious infections).
- Subjects that do not meet the enrollment criteria may not be enrolled. Any violations of these criteria will be reported in accordance with Institutional Review Board (IRB) policies and procedures study procedures.
Exclusion
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
5300 Patients enrolled
Trial Details
Trial ID
NCT01832324
Start Date
January 1 2011
End Date
December 1 2030
Last Update
September 26 2025
Active Locations (1)
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1
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104