Status:
TERMINATED
Anatomical and Functional Differences Between Continent and Incontinent Men Post Radical Prostatectomy
Lead Sponsor:
University of Michigan
Conditions:
Prostate Cancer
Post Prostatectomy Incontinence
Eligibility:
MALE
21+ years
Brief Summary
One out of every six men will be diagnosed with prostate cancer and post prostatectomy up to 75% report urinary incontinence. There are many hypotheses about the exact cause of post prostatectomy stre...
Eligibility Criteria
Inclusion
- Only men will be included since this is a study of post prostatectomy incontinence. Cases will be comprised of men who are post radical retropubic or laparoscopic (robotic) prostatectomy who have stress urinary incontinence based on history and a minimum of 50 grams of urine loss on 24 hour pad weights. Controls will be comprised of men who are post radical retropubic or laparoscopic (robotic) prostatectomy who do not have any kind or amount of incontinence based on history. Cases and controls will be matched for both age and race these have been shown to alter anatomical appearance of structures and lower urinary tract function.
Exclusion
- Criteria for both groups include urge incontinence, urinary retention, neurologic disease, insulin dependent diabetes, high dose steroid use, pre-surgical abnormal voiding function or incontinence, prior pelvic radiation or urologic surgery, any prior incontinence surgery, current medical therapy for incontinence or a perineal route of radical prostatectomy since this had been shown to give a distinctly different appearance on MRI compared to the laparoscopic or retropubic approach. Any patient with pelvic or systemic recurrence of their prostate cancer will also be excluded. Any man with relative or absolute contraindications to MRI such as implants or claustrophobia will be excluded.
Key Trial Info
Start Date :
May 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01832831
Start Date
May 1 2010
End Date
December 1 2014
Last Update
April 21 2016
Active Locations (2)
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1
VA Ann Arbor Healthcare System
Ann Arbor, Michigan, United States, 48105
2
University of Michigan
Ann Arbor, Michigan, United States, 48109