Status:
TERMINATED
Premature Ventricular Contractions (PVCs) and Blood Pressure Control
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Ventricular Premature Complexes
Blood Pressure
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine if reduction in premature ventricular contraction (PVC) burden results in a decrease in blood pressure, sympathetic outflow, plasma catecholamines and an impr...
Eligibility Criteria
Inclusion
- Frequent symptomatic premature ventricular contractions (PVCs) (\>10% of total QRSs on a 24-hour Holter)
- Willingness to participate in research
Exclusion
- Age \> 65 years old
- Pacemaker implantation
- Implantable cardioverter defibrillator implantation requiring pacing
- Sick sinus syndrome
- Atrio-ventricular (AV) block
- Left ventricular dysfunction defined as left ventricular ejection fraction \< 50%
- History of myocardial infarction or coronary artery disease
- Severe left ventricular hypertrophy (wall thickness \> 1.5 cm by echocardiography performed within 3 months from enrollment)
- Severe liver dysfunction
- Creatinine clearance of 35 mL/min/1.73 square meters or less
- Pregnancy
- Known hypersensitivity to the drug
- QRS duration \> 120 ms
- Recent change in blood pressure medication within 30 days of enrollment
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT01833455
Start Date
February 1 2013
End Date
June 1 2016
Last Update
February 22 2019
Active Locations (1)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53792