Status:
COMPLETED
Weight Loss Maintenance and Compensatory Mechanisms Activated With a Very-low Calorie Diet
Lead Sponsor:
Norwegian University of Science and Technology
Collaborating Sponsors:
St. Olavs Hospital
Conditions:
Obesity, Morbid
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Very-low calorie diets are relatively safe and effective in inducing significant weight loss, when used in selective individuals and under clinical supervision. However, weight loss maintenance in the...
Detailed Description
This study included a sub-study (n=30) to determine the timeline over which compensatory mechanisms (at both the level of energy expenditure and appetite control system) are activated with progressive...
Eligibility Criteria
Inclusion
- volunteers from Central Norway
- if female: taking oral contraceptives or post-menopausal
- body mass index 30-45 kg/m2
- stable weight (\<2kg variation in the last 3 months)
- not currently dieting to lose weight
Exclusion
- Pregnancy
- breast feeding
- drug or alcohol abuse within the last two years
- current medication known to affect appetite or induce weight loss
- enrollment in another obesity treatment program
- history of psychological disorders
- history of eating disorders
- history of diabetes type 1 or 2
- gastrointestinal disorders (particular cholelithiasis)
- kidney -, liver -, lung- or cardiovascular disease
- malignancies
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01834859
Start Date
August 1 2013
End Date
October 1 2016
Last Update
June 4 2020
Active Locations (1)
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1
St Olavs Hospital
Trondheim, Norway