Status:
UNKNOWN
Determinants of the Progression and Outcome of Mitral Regurgitation
Lead Sponsor:
Laval University
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Heart and Stroke Foundation of Canada
Conditions:
Mitral Valve Insufficiency
Eligibility:
All Genders
21+ years
Brief Summary
Mitral regurgitation (MR) is one of the most frequent valve lesions, both in North America and in Europe, and its prevalence is increasing with the aging of the population. Organic Mitral Regurgitatio...
Detailed Description
Mitral regurgitation (MR) is one of the most frequent valve lesions, both in North America and in Europe, and its prevalence is increasing owing to the aging of the population. There are 2 main catego...
Eligibility Criteria
Inclusion
- Age \> 18 or 21 years (Legal age according to the countries involved in this study)
- Presence of at least mild chronic OMR defined as an ERO ≥10mm2 and/or a regurgitant volume ≥20mL
Exclusion
- MR due to ischemic heart disease or cardiomyopathy
- \> mild mitral stenosis, aortic regurgitation, aortic stenosis or pulmonary stenosis
- previous valve operation
- history of myocardial infarction or angiographycally documented coronary stenosis
- congenital or pericardial heart disease
- endocarditis
- contra-indication or inability to exercise
- pregnancy
- Class I or IIa indication for mitral valve operation according to the 2014 ACC/AHA/ESC guidelines
- Typical contraindications to contrast-enhanced MRI (surgery in the last 3 months, defibrillator, pericardial electrodes, brain surgery, aneurysm clipping, neurostimulator, electric stimulation device or magnetically activated, cochlear implant, insulin pump or medication delivery device, Swan-Ganz catheter)
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
440 Patients enrolled
Trial Details
Trial ID
NCT01835054
Start Date
December 1 2008
End Date
March 1 2024
Last Update
October 28 2021
Active Locations (4)
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1
University Hospital of Sart Tilman
Liège, Belgium, 4000
2
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Canada, G1V4G5
3
University Hospital (CHU) of Brest, Hôpital La Cavale Blanche
Brest, France, 29609
4
University Hospital of Rennes
Rennes, France, 35033