Status:
COMPLETED
Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
Lead Sponsor:
Antonios Likourezos
Conditions:
Pain
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
The primary objectives of the study are to evaluate the efficacy of subdissociative dose intravenous ketamine compared with intravenous morphine in relieving acute pain in the ED. Secondary objectives...
Detailed Description
Rationale: Opioids are traditionally accepted as a cornerstone of acute pain management in the Emergency Department (ED). Morphine is one of the most commonly used parenteral opioid analgesics whose i...
Eligibility Criteria
Inclusion
- ED patients18-55 years old presenting with moderate to severe (Numeric Pain Rating Score \>5) acute (less than 7 days)
- abdominal, flank, back or musculoskeletal pain warranting (in the treating physician's judgment) administration of intravenous opioid pain medication.
- Patients must be awake, alert and oriented to time, place and person,
- patient must be able to demonstrate understanding of the informed consent.
- Patient must be able to verbalize how much pain they are having on the 10 point Numeric Rating Pain Scale,
- Patient mus be able to verbalize the nature of the side effects he may be experiencing from the intravenous analgesia.
Exclusion
- Pregnancy or breast feeding
- SBP\<90
- Weight greater than 115kg or less than 45kg,
- altered mental status,
- allergy to ketamine or morphine,
- history of acute head or ocular trauma
- presence of intracranial mass or vascular lesion, presence of psychiatric history
- diagnosis or treatment (as assessed by electronic chart review).
- history of seizure or intracranial hypertension
- history of chronic pain, pain syndrome or fibromyalgia
- presence of cardiovascular disease except controlled hypertension
- history of acute head or ocular trauma, drug or alcohol abuse in the preceding 6 months
- drugs or alcohol abuse in the preceding 6 months
- SBP\>180
- HR\<50
- HR\>150
- RR\<10
- RR\>30
- administration of opiate pain medication in the past 4 hours prior to assessment (i.e. home, EMS, triage, office, etc.)
- presence of renal or hepatic insufficiency (as assessed by electronic chart review),
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT01835262
Start Date
April 1 2013
End Date
May 1 2014
Last Update
February 29 2016
Active Locations (1)
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1
Maimonides Medical Center
Brooklyn, New York, United States, 11219