Status:
COMPLETED
Effects of USP Methylene Blue on Cognitive and fMRI Brain Activity
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Conditions:
Brain Activity
Eligibility:
All Genders
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of the study is to evaluate whether low-dose USP methylene blue (MB) will: i) improve short-term memory retention in a delayed match-to-sample task, ii) reduce reaction time in a psychomot...
Detailed Description
Self-declared healthy adult volunteers will be studied using a double-blind, placebo-controlled design. After informed consent and familiarity with the tasks and the MRI environment, the subject will ...
Eligibility Criteria
Inclusion
- Age 18 - 65 years, self declared healthy individuals
- English speaker and be able to give consent
Exclusion
- Contraindication for MRI (pacemaker, metal implants, etc.)
- Claustrophobia
- Pregnant (child-bearing age females will be tested to exclude pregnancy onsite)
- Breast-feeding
- A history of hypersensitivity or allergy to methylene blue, glucose-6-phosphate dehydrogenase deficiency (determined via questionnaire)
- Neurological, mental, or cardiovascular disorders
- Liver, kidney disorders, kidney or liver transplant, hypertension, diabetes, etc.
- Known hypersensitivity to thiazide diuretics and phenothiazines
- A history of a psychotic disorder or panic disorder, violent or suicidal behavior, psychiatric institutionalization or imprisonment
- Any other condition, which in the opinion of the investigator, would put the participant at risk and warrant exclusion from the study
- Methemoglobinemia
- On any psychiatric serotonergic antidepressant medication or drugs of abuse currently or within the last 5 weeks
- History of panic attack
- Color Blindness
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01836094
Start Date
August 1 2013
End Date
March 1 2016
Last Update
April 11 2017
Active Locations (1)
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1
Research Imaging Institute, The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229