Status:
COMPLETED
Isotoxic Intensity Modulated Radiotherapy (IMRT) in Stage III Non Small Cell Lung Cancer (NSCLC) - A Feasibility Study
Lead Sponsor:
Prof Corinne Faivre-Finn
Collaborating Sponsors:
Cancer Research UK
British Lung Foundation
Conditions:
Non Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study is for patients having a course of chest radiotherapy treatment after receiving chemotherapy for the treatment of non-small cell lung cancer. Patients with non-small cell lung cancer have a...
Detailed Description
Background: Approximately 12,000 patients are diagnosed with stage III NSCLC in the UK each year and their survival is \~15% at 5 years. As the majority of patients are not suitable for the gold stan...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed NSCLC
- Inoperable Stage III disease (T3N1-3, any T4, any N2 -3) confirmed by PET scanning, mediastinoscopy or thoracoscopy
- Patients treated with at least 2 cycles of platinum based induction chemotherapy and able to start radiotherapy within 5 weeks of the last cycle of chemotherapy
- Tumour judged inoperable by a lung MDT
- Age 18+, no upper age limit
- Performance status (PS) - ECOG 0-2. Patients with PS 2 whose general condition is explained by disease can be included at the discretion of the local investigator. Patients with PS 2 as a result of co-morbid conditions will be excluded
- Patient considered suitable for radical RT
- Tumour that can be encompassed within a radical RT treatment volume (MLD expected to be \<20Gy)
Exclusion
- Patients suitable for standard concurrent CTRT
- Patients only suitable for radical RT due to PS and co-morbidities
Key Trial Info
Start Date :
April 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2018
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT01836692
Start Date
April 1 2014
End Date
June 1 2018
Last Update
October 31 2018
Active Locations (7)
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1
Belfast Health & Social Care NHS Trust - Northern Ireland Cancer Centre
Belfast, United Kingdom
2
Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital
Cambridge, United Kingdom
3
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
4
Leeds Teaching Hospitals NHS Trust - St James's University Hospital
Leeds, United Kingdom