Status:
COMPLETED
Angiogenesis and Fibrosis in Aortic Stenosis
Lead Sponsor:
University of Edinburgh
Conditions:
Aortic Stenosis
Fibrosis
Eligibility:
All Genders
40+ years
Brief Summary
Angiogenesis and fibrosis lie at the heart of a number of fundamental processes responsible for cardiovascular disease. In this proposal, the investigators intend to build upon a highly successful pro...
Detailed Description
Integrins Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β su...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- asymptomatic mild (peak valve velocity of 2-5-3.0 m/s; n=10), moderate (peak valve velocity of 3.0-4.0 m/s; n=10) or severe aortic stenosis (peak valve velocity of \>4.0 m/s; n=10) and 10 patients with severe aortic stenosis proceeding to aortic valve replacement.
- Healthy control subjects (n=10) will have no past medical history of ischaemic heart disease or valvular heart disease and have a structurally normal heart on echocardiography.
- Exclusion Criteria:
- Atrial fibrillation
- Hepatic failure (Childs-Pugh grade B or C)
- Renal failure (estimated glomerular filtration rate \<25 mL/min)
- Women of child-bearing potential
- Contraindication to magnetic resonance imaging
- Inability to undergo scanning
- Ochronosis and those with any form of collagen-vascular disease.
Exclusion
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01837160
Start Date
April 1 2013
End Date
August 1 2015
Last Update
August 30 2016
Active Locations (1)
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1
University of Edinburgh
Edinburgh, Lothian, United Kingdom, EH16 4TJ