Status:
COMPLETED
PaNeX: Partial Nephrectomy Under Xenon
Lead Sponsor:
RWTH Aachen University
Collaborating Sponsors:
German Research Foundation
Conditions:
Renal Function After Partial Nephrectomy
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Purpose of this study is to determine whether Xenon - as compared to Isoflurane - shows a nephroprotection after partial nephrectomy.
Detailed Description
A partial nephrectomy is accompanied by ischemia time, followed by reperfusion. This frequently leads to a kidney injury of the remained tissue and decrease of the renal function after surgery. As it ...
Eligibility Criteria
Inclusion
- Patients willing and able to complete the requirements of this study
- Patients with renal carcinoma restricted to one kidney
- Patients undergoing partial nephrectomy
- Men and women \>= 18 yrs
- Informed consent
Exclusion
- Chronic renal failure with a GFR \< 60ml/min/1,73m2 body surface area
- American Society of Anesthesiologists (ASA)\>III
- Hypersensitivity to the study anaesthetics
- Chronic obstructive pulmonary disease (COPD) GOLD IV
- Acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support
- Severe cardial dysfunction New York Heart Association (NYHA) \>III
- Disabling neuropsychiatric disorders
- Increased intracranial pressure
- pregnant or breastfeeding women
- Women of childbearing potential
- Presumed uncooperativeness or legal incapacity
- Lack of informed consent
- Participation in a concomitant trial within the last 30 days
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT01839084
Start Date
July 1 2013
End Date
February 1 2016
Last Update
February 18 2016
Active Locations (1)
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1
Department of Anesthesiology, University Hospital Aachen
Aachen, North Rhine-Westphalia, Germany, 52074