Status:
COMPLETED
China Antihypertensive Trial in Acute Ischemic Stroke
Lead Sponsor:
Tulane University
Collaborating Sponsors:
Soochow University
Conditions:
Ischemic Stroke
Eligibility:
All Genders
22+ years
Phase:
NA
Brief Summary
This randomized trial tests the effect of early blood pressure reduction on major disability and death among patients with acute ischemic stroke in china.
Detailed Description
We designed a randomized controlled clinical trial to test: * The effectiveness of blood pressure reduction among patients with acute ischemic stroke (within 48 hours of onset) on the primary outcome...
Eligibility Criteria
Inclusion
- Age ≥22 years
- Ischemic stroke onset within 48 hours confirmed by imaging (CT scan or MRI) study
- Systolic BP≥140 and \<220 mm Hg and diastolic BP≥80 mm Hg
- No contraindications to antihypertensive treatment
- Able and willing to sign informed consent by patients or their direct family members
Exclusion
- Individuals with hemorrhagic stroke
- Individuals with severe heart failure (NY Heart Association class III and IV), myocardial infarction, unstable angina, aortic dissection and cerebrovascular stenosis
- Individuals in a deep coma
- Individuals with resistant hypertension \[systolic BP ≥170 mm Hg despite use of 4 or more antihypertensive medications for half a year or longer\]
- Intravenous thrombolytic therapy (such as intravenous rtPA)
- Individuals who are unable to participate in follow-up examination
- Current pregnant women
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2016
Estimated Enrollment :
4071 Patients enrolled
Trial Details
Trial ID
NCT01840072
Start Date
August 1 2009
End Date
May 1 2016
Last Update
March 27 2024
Active Locations (1)
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1
Soohow University
Suzhou, Jiangsu, China, 215123