Status:
UNKNOWN
Prenatal Screening for Imprinting Anomalies Implicated in Beckwith Wiedemann and Silver Russell Syndromes
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Pregnant Women Requiring Amniocentesis
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
Losses of imprinting are involved in various syndromes. Those occurring in the 11p15 region lead to Beckwith-Wiedemann and Silver-Russell Syndromes. These losses of imprinting follow a mosaic pattern,...
Detailed Description
To evaluate the agreement between the methylation index of the 11p15 region obtained using DNA extracted from amniocytes and that extracted from cord blood leukocytes, by calculating the intraclass co...
Eligibility Criteria
Inclusion
- Pregnant women, 18 years of age or older
- Requiring amniotic fluid sampling in the context of pregnancy care after 15 weeks of amenorrhea
- Having provided written informed consent
- Followed at Trousseau Hospital or Clinique des Bluets during their pregnancy
- Covered by or beneficiary of a state health insurance program (except for medical aid programs)
Exclusion
- Warning signs on ultrasound that require a medical termination of pregnancy to be discussed even before amniocentesis is performed
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT01842659
Start Date
May 1 2013
End Date
October 1 2016
Last Update
August 24 2016
Active Locations (1)
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1
Explorations fonctionnelles endocriniennes
Paris, France, 75012