Status:
COMPLETED
Syndecan-4 as a Biomarker in Patients With Chagas Disease
Lead Sponsor:
Hospital Sao Rafael
Conditions:
Chagas Disease
Eligibility:
All Genders
18-70 years
Brief Summary
The purpose of this study is to analyze the efficacy of syndecan-4 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of th...
Detailed Description
Increased serum levels of syndecan-4 have been correlated to acute myocardial infarction and chronic heart failure, suggesting that this molecule can be an important biomarker in heart diseases. In sp...
Eligibility Criteria
Inclusion
- Chagas disease diagnosis confirmed by 2 different serologies
- Diagnosis of Chagas disease in both forms: indeterminate and cardiac ones, with and without ventricular dysfunction.
Exclusion
- Significant valve disease defined as aortic stenosis with a gradient of VE/Ao \> 50 mmHg
- Mitral stenosis with a valve area inferior than 1,5 cm2
- Superior or moderated aortic and/or mitral regurgitation
- Chronic use of immunosuppressive agents
- Dialysis treatment of terminal renal failure
- Fever on the last 48 hours or evidence of systemic infection in activity according to the definition of sepsis of the ACCP/SCCM (American College os Chest Physicians/Society of Critical Care Medicine)
- Current abusive use of alcohol or illicit drugs (Based on the DSM IV)
- Any other comorbidities that impact patient's survival within the next 2 years
- Liver disease in activity
- Continuous use of steroids as treatment for COPD
- Hematologic, neoplastic or bone diseases
- Homeostasis disturbances
- Inflammatory diseases or chronic infectious diseases
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01842867
Start Date
January 1 2011
End Date
June 1 2015
Last Update
October 12 2015
Active Locations (1)
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1
Hospital São Rafael
Salvador, Estado de Bahia, Brazil, 41253-190