Status:
COMPLETED
MicroRNAs as Biomarkers in Patients With Chagas Disease
Lead Sponsor:
Hospital Sao Rafael
Conditions:
Chagas Disease
Eligibility:
All Genders
18-70 years
Brief Summary
The purpose of this study is to analyze the efficacy of MicroRNAs as biomarkers on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this...
Detailed Description
The patients included in the study must at first sign the written consent. They shall be accompanied in the specialized outpatient clinics for Chagas disease - Hospital São Rafael - Centro de Biotecno...
Eligibility Criteria
Inclusion
- Chagas disease diagnosis confirmed by 2 different serologies
- Diagnosis of Chagas disease in both forms: indeterminate and cardiac ones, with and without ventricular dysfunction.
Exclusion
- Significant valve disease defined as aortic stenosis with a gradient of VE/Ao \> 50 mmHg
- Mitral stenosis with a valve area inferior than 1,5 cm2
- Severe or moderate aortic and/or mitral regurgitation
- Chronic use of immunosuppressive agents
- Dialysis treatment of terminal renal failure
- Fever on the last 48 hours or evidence of systemic infection in activity according to the definition of sepsis of the ACCP/SCCM (American College os Chest Physicians/Society of Critical Care Medicine)
- Current abusive use of alcohol or illicit drugs (Based on the DSM IV)
- Any other comorbidities that impact patient's survival within the next 2 years
- Liver disease in activity
- Continuous use of steroids as treatment for COPD
- Hematologic, neoplastic or bone diseases
- Homeostasis disturbances
- Inflammatory diseases or chronic infectious diseases
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01842880
Start Date
January 1 2011
End Date
December 1 2013
Last Update
February 20 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital São Rafael
Salvador, Estado de Bahia, Brazil, 41253-190