Status:
COMPLETED
Phase 1 Study Testing the Combination of Aflibercept and Capecitabine in Metastatic Digestive and Breast Cancers
Lead Sponsor:
Jules Bordet Institute
Conditions:
Metastatic Colorectal Cancers
Metastatic Gastric Cancers
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Prospective non randomized, non-comparative, dose escalation, two arms open phase I trial to assess the safety and tolerability of capecitabine given in combination with aflibercept in patients with m...
Detailed Description
Aflibercept has been found to be active with a broad pharmacological index against early and advanced stage disease in a variety of preclinical solid tumor models including sarcomas, and ovarian, pros...
Eligibility Criteria
Inclusion
- Histologically confirmed digestive or breast cancer that is metastatic or unresectable, for which no curative measures are possible, and chemorefractory to all known medications in the respective fields.
- Age ≥ 18 years.
- Life expectancy of greater than 12 weeks.
- ECOG (Eastern Cooperative Oncology Group) performance status ≤ 1.
- Normal organ and marrow function as defined below:
- Leukocytes \> 3,000/microLiter (mcL)
- Hb\>10g/mcL
- Absolute neutrophil count \> 1,500/mcL
- Platelets \> 100,000/mcL
- Total bilirubin within 2 × institutional upper limit of normal
- AST (aspartate amino transferase)/ALT (alanine amino transferase)/ALKP (Alkaline Phosphatase) levels \< 5 × institutional upper limit of normal for liver metastases, \< 2.5 ULN (Upper Limit of Normal) in case of no liver metastases
- Creatinine within 2 × institutional upper limit of normal or creatinine clearance \> 35 mL/min
- Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
- Signed written informed consent (approved by an Independent Ethics Committee (IEC)) obtained prior to any study specific baseline procedures.
Exclusion
- Patients with malabsorption or dysfunctional GI tract.
- Participants who have had chemotherapy or radiotherapy (except limited radiotherapy for bone metastasis for instance) within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
- Participants should not receive any other experimental agents.
- Participants with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
- History of cardiovascular ischemic disease or cerebrovascular incident within the last six months, NYHA class III and IV congestive heart failure.
- Intolerance to atropine sulfate or loperamide
- Known dihydropyrimidine dehydrogenase deficiency
- Treatment with CYP3A4 inducers unless discontinued \> 7 days prior to randomization
- Any of the following in 3 months prior to inclusion: grade 3-4 gastrointestinal bleeding (unless due to resected tumor), treatment resistant peptic ulcer disease, erosive esophagitis or gastritis, infectious or inflammatory bowel disease, or diverticulitis.
- Major surgery within 6 weeks.
- Uncontrolled concurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- Pregnant women, lactation or refusal to use adequate contraceptive measures (hormonal or barrier method of birth control, abstinence).
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT01843725
Start Date
September 1 2013
End Date
October 1 2016
Last Update
January 31 2018
Active Locations (1)
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1
Institut Jules Bordet
Brussels, Belgium, 1000