Status:
COMPLETED
Phase I Study With Sorafenib in Addition to Vinflunine in Metastatic Transitional Cell Carcinoma of the Urothelial Tract
Lead Sponsor:
Dr Anders Ullén
Collaborating Sponsors:
Bayer
Pierre Fabre Laboratories
Conditions:
Urothelial Carcinoma
Bladder Cancer
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
This study aims to analyse the tolerability (side effects and safety) with standard treatment (Javlor®) with the addition of a second anti-tumour drug: sorafenib (Nexavar®). This is the first time thi...
Detailed Description
Objectives * To explore the safety of sorafenib in combination with vinflunine in patients with transitional cell carcinoma of the urothelial tract and to define a recommended phase II dose for this ...
Eligibility Criteria
Inclusion
- signed informed consent;
- histologically confirmed transitional cell (pure or mixed histology including transitional cell carcinoma are allowed) carcinoma of the urothelial tract;
- patients who have received neoadjuvant or adjuvant platinum-containing chemotherapy and who are diagnosed with locoregional recurrent or metastatic disease prior to or at the 6-months" visit , are eligible or
- patients who have received palliative platinum-containing chemotherapy and who are diagnosed with progression prior to or at the 6-months" visit, are eligible or
- patients who have contraindication to platinum-containing chemotherapy;
- previous systemic chemotherapy must have been stopped 14 days before the inclusion with recovery (G1 or less) from any treatment related toxicity;
- measurable and/or non-measurable disease using RECIST and defined as: Measurable disease: lesions that can be measured in at least one dimension and which have not been previously irradiated. Longest diameter 20 mm with conventional techniques or 10 mm with spiral CT scan or MRI. Non-measurable disease: lesions which have not been previously irradiated, or longest diameter \<20 mm with conventional techniques or \<10 mm with spiral CT scan or MRI, or truly non measurable lesions including bone lesions, ascites, pleural/pericardial effusion, and lymphangitis cutis/pulmonitis;
- age 18 up to 80 years;
- ECOG / WHO Performance Status (PS) ≤1;
- haematological function: haemoglobin ≥100 g/L absolute neutrophil count 1.0 x LL (lower limit of normal value) platelets 100 x 109/L;
- hepatic function: bilirubin \<1.5 x ULN\*, transaminases \<2.5 x ULN\*
- \*ULN = upper limit of normal value
- renal function: creatinine clearance 40 ml/min (measured by either iohexol clearance or Cr-EDTA technique);
- Clinically normal cardiac function based on ejection fraction (LVEF assessed by MUGA or ECHO, LVEF ≥50%);
- able to swallow and retain oral medication;
- previous treatment related toxicity must be grade ≤1 at time of inclusion and no presence of asthenia, hand-foot skin reaction or rash grade \>1 (NCI CTCAE v4.0) at enrolment;
- no known or suspected allergy to the investigational agent or any agents given in association with this trial;
Exclusion
- non-transitional cell carcinoma of the urothelial tract (e.g. pure adenocarcinoma or squamous cell carcinoma);
- prior treatment with vinflunine;
- diagnosed brain metastases or leptomeningeal involvement. Brain CT-scans or MRI are not required unless there is clinical suspicion of central nervous system involvement.
- peripheral neuropathy G3 (NCI CTCAE v4.0);
- history of serious or concurrent illness or uncontrolled medical disorder; any medical condition that might be aggravated by treatment or which could not be controlled: active infection requiring antibiotics within 2 weeks before the study inclusion, unstable diabetes mellitus, uncontrolled hypercalcaemia \>2.9 mmol/L (or \>G2 NCI CTCAE v4.0), concurrent congestive heart failure NYHA (class III-IV) or any type of angina pectoris and/or a diagnosis of myocardial infarction during the previous 6 months and/or poorly controlled hypertension will be excluded, QTc \>450 ms at baseline, additional risk factors for Torsade de Pointes (heart failure and hypokalemia (≥G1, i.e. P-K \<LLN-2.5 mM) or family history of long QT-syndrome), cardiac arrhythmias requiring anti-arrhythmics (excluding beta-blockers or digoxin for chronic atrial fibrillation);
- patients having received more than one previous systemic chemotherapy for advanced or metastatic disease;
- patients who have received any other investigational or anti-cancer therapy 14 days before the inclusion;
- other malignancies, except adequately treated basal carcinoma of the skin or in-situ cervix carcinoma or incidental prostate cancer (T1a, Gleason score ≤6, PSA \<0.5 ng/ml), or any other tumour with a disease free survival of ≥5 years;
- pregnant or lactating women;
- men or women of childbearing potential not employing adequate contraception;
- any psychological, familial, sociological, or geographical condition which does not permit protocol compliance and medical follow-up.
- poorly controlled hypertension. At baseline, blood pressure \>150/90 is defined as poorly controlled.
- renal dysfunction: creatinine clearance \<40 ml/min measured by either iohexol clearance or Cr-EDTA technique.
- ECOG / WHO Performance Status ≥2
- presence of hand-foot skin reaction or rash \>G1 at enrolment;
- known or suspected allergy to the investigational agent or any agents given in association with this trial;
- current medical treatment with any compound that prolongs QTc
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 5 2018
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01844947
Start Date
May 1 2012
End Date
June 5 2018
Last Update
April 26 2019
Active Locations (3)
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1
Department of Oncology, Aarhus University Hospital
Aarhus, Denmark, DK-8200
2
Department of Oncology, Rigshospitalet
Copenhagen, Denmark, DK-2100
3
Department of Oncology, Karolinska University Hospital
Stockholm, Sweden, SE-171 76