Status:
UNKNOWN
Perceptual Decision Making Under Conditions of Visual Uncertainty
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
The Dana Foundation
Conditions:
Parkinson's Disease
Dystonia
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
In this proposal the investigators have three Specific Aims using human patient populations as model systems; 1) identify a role for the Basal Ganglia (BG) in perceptual decision making; 2) determine ...
Detailed Description
In this study, the investigators aim determine whether patients with Parkinson's disease (PD) have altered perceptual decision-making. The results of these experiments will shed important light on som...
Eligibility Criteria
Inclusion
- Group 1 - Age and Sex matched healthy controls:
- Age 18-80 Years
- Group 2 - Patients with Parkinson's Disease - No DBS:
- "on meds" and "off meds" (tested in separate sessions) - total of 2 sessions
- Age 45-80 Years
- Unified PD rating scale (UPDRS)
- Mini mental health Status (MMHS)
- Group 3 - Patients with Parkinson's Disease already consented for DBS (STN):
- Age 45-80 Years
- Unified PD rating scale (UPDRS)
- Mini mental health Status (MMHS)
- Group 4 - Patients with Parkinson's Disease already consented for DBS (GPi):
- Age 45-80 Years
- Unified PD rating scale (UPDRS)
- Mini mental health Status (MMHS)
- Group 5 - Patients with Cervical Dystonia - No DBS
- Age 30-80 years
- Fahn-Marsden dystonia rating scale (FMDRS)
- Mini mental health Status (MMHS)
- Group 6 - Patients with Generalized Dystonia (Ach) - No DBS:
- Age 30-80 years
- Fahn-Marsden dystonia rating scale (FMDRS)
- Mini mental health Status (MMHS)
- Group 7 - Patients with Dystonia already consented for DBS (GPi):
- Age 30-80 years
- Fahn-Marsden dystonia rating scale (FMDRS)
- Mini mental health Status (MMHS)
- Group 8 - Patients Cerebellar Stroke
- Age 30-80 Years
- Routine neuro exam
- Mini mental health Status (MMHS)
- Group 9 - Patients Cerebellar Ataxia
- Age 30-80 Years
- Routine neuro exam
- Mini mental health Status (MMHS)
Exclusion
- Visual impairment or ocular motility disorder Inability to sit for the 30 minute task plus 20-30 minute instruction time, setup, and wait time.
- For Group 1 (Age Sex Matched Controls), there will additional exclusion criteria of other neurological disease and drug use
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2016
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01845883
Start Date
April 1 2013
End Date
December 1 2016
Last Update
December 18 2015
Active Locations (1)
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1
Neuroscience Research Building
Los Angeles, California, United States, 90095