Status:
TERMINATED
DIM as a Treatment for Thyroid Disease
Lead Sponsor:
The New York Eye & Ear Infirmary
Conditions:
Proliferative Thyroid Disease
Eligibility:
All Genders
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
Diindolylmethane (DIM), a dietary supplement, found naturally in cruciferous vegetables (such as cabbage, cauliflower, broccoli, \& Brussels sprouts) has been studied extensively in recent years for i...
Eligibility Criteria
Inclusion
- Adults diagnosed with abnormalities of the thyroid gland suspicious for benign adenoma, or goiterous changes.
Exclusion
- Patients who are pregnant, attempting to conceive, or lactating will be excluded due to possible deleterious effects of treatment on fetus/infant. Patients taking oral contraceptives, estrogen therapy, tamoxifin or those with a history of breast cancer will be excluded. Patients with liver disease and those taking statins for hypercholesterolemia will also be excluded to decrease the potential for possible liver toxicity. Any patient with elevated liver enzymes on pretreatment blood screening will be excluded from study participation. Patients with serious systemic diseases such as renal failure, diabetes, blood dyscrasia, coagulopathy, and non-optimized cardiopulmonary disease will be excluded due to the possibility of confounding blood tests screening for toxicity.
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT01846364
Start Date
November 1 2006
End Date
September 1 2011
Last Update
May 3 2013
Active Locations (1)
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1
The New York Eye & Ear Infirmary
New York, New York, United States, 10003