Status:
COMPLETED
Cerebrospinal Fluid Endostatin/Collagen XVIII Concentrations in Patients With Severe Traumatic Brain Injury
Lead Sponsor:
Shanghai 6th People's Hospital
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
16-82 years
Brief Summary
Angiogenesis is an important pathophysiological response to traumatic brain injury (TBI) and modulated by pro- and anti-angiogenic factors. Recent studies have suggested that endogenous angiogenesis i...
Detailed Description
Patients with severe TBI (Glasgow Coma Scale score of 8 or less) requiring continuous lumbar drainage of CSF were included in the study. Patients delivered within 4 h whose highest abbreviated injury ...
Eligibility Criteria
Inclusion
- Patients with severe TBI (GCS score of 8 or less) requiring continuous lumbar drainage of CSF. Patients delivered within 4 h whose highest abbreviated injury score (AIS) was 3 or less (other than head injury) were considered to be isolated TBI cases and were included.
Exclusion
- Patients who suffered open or combined injuries, had existing prior neurological disease were excluded. Those who died within the first week of hospitalization and/or whose serial CSF samples could not be obtained were also excluded as having incomplete data.
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Key Trial Info
Start Date :
October 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01846546
Start Date
October 1 2006
End Date
April 1 2008
Last Update
September 7 2020
Active Locations (1)
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1
Shanghai Sixth People's Hospital
Shanghai, China, 200233