Status:
COMPLETED
Iron Status and Hypoxic Pulmonary Vascular Responses
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
National Institute for Health Research, United Kingdom
British Heart Foundation
Conditions:
Lung Hypoxia
Pulmonary Arterial Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
On exposure to hypoxia (low oxygen) the normal response is for pulmonary arterial systolic blood pressure (PASP, blood pressure through the lungs) to increase. We have previously shown that raising ir...
Eligibility Criteria
Inclusion
- Willing and able to give informed consent for participation in the study
- Men and women aged 18 years or older and generally in good health
- Detectable tricuspid regurgitation on echocardiography during both normoxia and hypoxia enabling measurement of pulmonary arterial pressure
- For iron-deficient volunteers: ferritin ≤15microg/L and transferrin saturation \<16%
- For iron-replete volunteers: ferritin ≥20microg/L and transferrin saturation ≥20%
Exclusion
- Haemoglobin \<8.0g/dl
- Haemoglobinopathy
- Iron overload defined as ferritin \>300microg/L
- Hypoxia at rest or on walking (SaO2 \<94%) or significant comorbidity that may affect haematinics, pulmonary vascular or ventilatory responses, e.g. current infection, a chronic inflammatory condition, known cardiovalvular lesion or pulmonary hypertension, uncontrolled asthma or chronic obstructive pulmonary disease
- Exposure to high altitude (\>2,500m) within the previous six weeks or air travel \>4 hours within the previous week
- Iron supplementation or blood transfusion within the previous 6 weeks
- Pregnancy or breast feeding
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT01847352
Start Date
February 1 2013
End Date
April 1 2014
Last Update
May 6 2016
Active Locations (1)
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1
University of Oxford Department of Physiology, Anatomy and Genetics
Oxford, Oxfordshire, United Kingdom, OX1 3PT