Status:
UNKNOWN
Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure
Lead Sponsor:
Haukeland University Hospital
Conditions:
Addison Disease
Eligibility:
FEMALE
18-70 years
Phase:
PHASE2
Brief Summary
The conventional glucocorticoid replacement therapy in primary adrenal insufficiency- Addison's disease,renders the cortisol levels unphysiological, which may cause symptoms and long-term complication...
Detailed Description
Addison's disease occurs when more than 90% of the adrenal cortex is destroyed. Cortisol levels in serum vary throughout the day. In addition to the daily need, cortisol increases in response to all f...
Eligibility Criteria
Inclusion
- patients with Addison's disease
Exclusion
- Type 1 diabetes
- malignant disease
- pregnant women
- cardiac disease
- lung disease
- neuromuscular diseases
- pharmacological treatment with glucocorticoids or drugs that interfere with cortisol metabolism (anti-epileptics, rifampicin, St Johns wart, oral estrogens, antidepressives).
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2014
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01847690
Start Date
June 1 2013
End Date
March 1 2014
Last Update
December 2 2013
Active Locations (1)
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1
Haukeland Universitetessykehus, Department of Medicine
Bergen, Norway, Norway, 5021