Status:
UNKNOWN
Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism
Lead Sponsor:
Shandong Provincial Hospital
Conditions:
Hypothyroidism
Thyroid Diseases
Eligibility:
All Genders
40-75 years
Phase:
PHASE4
Brief Summary
Hypothyroidism is a common clinical entity which is often complicated by dyslipidemia. It is also reported increased risk for incidence of atherosclerosis and resulting coronary heart disease(CHD), he...
Eligibility Criteria
Inclusion
- 40\~75 years old
- Diagnosis of overt or subclinical hypothyroidism in two occasions with a minimum interval period of three months
Exclusion
- Pregnant or lactating women
- Severe hepatic or renal dysfunction
- Psychiatric disabilities, acute cardiovascular and cerebrovascular diseases, chronic respiratory diseases, familiar hypercholesterolemia, malignancy, cholelithiasis, pancreatitis, bowel diseases and other disorders influencing lipid and bile acid metabolism
- Taking lipid-lowering agents and other drugs influencing thyroid function, lipid and bile acid metabolism
- Obviously poor compliance.
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2023
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT01848171
Start Date
July 1 2013
End Date
July 1 2023
Last Update
January 18 2023
Active Locations (1)
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1
Shandong Provincial Hospital
Jinan, Shandong, China, 250021