Status:
COMPLETED
Study of Brain Circuitry in Anxiety Disorders
Lead Sponsor:
Mclean Hospital
Conditions:
Posttraumatic Stress Disorder
Panic Disorder
Eligibility:
All Genders
18-65 years
Brief Summary
A diverse body of research has implicated the amygdalo-cortical circuitry in the pathophysiology of anxiety disorders. For example, one model of PTSD posits exaggerated amygdala responsivity to threat...
Detailed Description
All candidates for this project will undergo a comprehensive clinical assessment by an investigator trained to administer these instruments. At the MGH fMRI Center in Charlestown or at the Neuroimagin...
Eligibility Criteria
Inclusion
- 18 - 65 years of age
- Right-handed (Edinburgh Inventory - Oldfield 1971)
- SCID diagnosis consistent with group designation:
- Current PTSD (PTSD group; none current or past (NC and TENC group); Current SP (must be to small animal phobia, SP group); Current PD (PD group)
- To be matched for age, gender, and years of education, as well as self-identified race/ethnicity.
- For female subjects, stage of menstrual cycle will be ascertained by history (see appendix), and dates of fMRI acquisition will be scheduled to prevent systematic differences between groups with respect to this variable.
Exclusion
- Neurologic or medical condition that would interfere with study procedures or confound results, ascertained by history.
- History of seizure or significant head trauma (i.e., extended loss of consciousness, neurological sequelae, or known structural brain lesion)
- History of exclusionary Axis I psychiatric diagnosis (other than as specified); i.e., history of substance use disorder, psychotic disorder, bipolar disorder, tic disorder, or eating disorder. Note that comorbid current major depressive disorder will be allowed in up to one half of each study group. This will enable inclusion of this common comorbidity, but also enable a definitive assessment of whether or not the presence of this comorbid diagnosis is driving any observed significant between group differences.
- Use of psychotropic medication within 4 weeks prior to study (within 6 weeks for fluoxetine, or other long-lived compounds; within one year for neuroleptics).
- Pregnancy (to be ruled out by urine ß-HCG).
- Metallic implants or devices contraindicating magnetic resonance imaging.
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT01849432
Start Date
December 1 2006
End Date
July 1 2011
Last Update
May 8 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
McLean Hospital
Belmont, Massachusetts, United States, 02478