Status:
UNKNOWN
Enhancement of Neurocognitive Functions by Hippocampal Sparing Radiotherapy
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Conditions:
Radiation of Neurocranial Region
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This randomized trial examines possible enhancements in live quality and neurocognitive functions in patients after radiotherapy of the neurocranial area with hippocampal sparing. Although the hippoca...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- minimum age 18
- diseases indicating a radiotherapy of neurocranial area (histologically or image-guided confirmed (skull base)meningioma,pituitary adenoma,brain metastases, SCLC)
- indication for a local radiotherapy in neurocranial area or for a radiation of whole neurocranium
- Karnofsky-State ≥ 50%
- patient has understand content of study protocol
- Signed study-specific consent form prior to therapy
- Exclusion Criteria
- pregnant or nursing women
- Fertile patients who refuse effective contraception during study treatment
- persistent drug and/or alcohol abuse
- prior radiotherapy of neurocranial region
- patients not able or willing to behave according to study protocol
- in the case of malignancy: more than 3 brain metastases
- in the case of malignancy: brain metastases in hippocampal region or in the hippocampus avoidance zone
- GTV in hippocampal region or in the hippocampus avoidance zone
- patients in care
- patients who are not able to speak German
- conditions that preclude the application of MRT (e.g. magnetic implants, cardiac pacemaker)
- on-treatment participation on other trials
Exclusion
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2021
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01849484
Start Date
March 1 2013
End Date
April 1 2021
Last Update
August 1 2016
Active Locations (1)
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1
Universitätsklinikum Erlangen
Erlangen, Germany, 91054