Status:
COMPLETED
The Effect of Continuous Positive Airway Pressure on Diastolic Function in Patients With Obstructive Sleep Apnea
Lead Sponsor:
Yonsei University
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
20-75 years
Phase:
NA
Brief Summary
The association of obstructive sleep apnea (OSA) and cardiac diastolic dysfunction have been reported, and improvement of diastolic function after continuous positive airway pressure (CPAP) in OSA pat...
Eligibility Criteria
Inclusion
- Patietns≥20 and ≤75 years-old
- Patients who diagnosed as obstructive sleep apnea and AHI\>30 on polysomnography
Exclusion
- Age \< 20 years-old
- Left ventricular dysfunction (LVEF\<50%) or structural heart disease on transthoracic echocardiography
- Diabetes mellitus
- Significant cardiac valvular disease (≥moderate)
- Severe hypertension (\>180/110mmHg)
- Moderate or severe kidney disease (eGFR \< 60 mL/min )
- Clinically significant liver disease
- History of coronary artery disease
- malignancy or autoimmune disease
- Acute/chronic infection status
- Pregnant status
- Patients taking anxiolytics or sedatives
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01854398
Start Date
May 1 2013
End Date
June 1 2016
Last Update
January 26 2017
Active Locations (1)
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1
Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine
Seoul, Seoul, South Korea, 120-752