Status:
UNKNOWN
Ovulation Induction With Clomiphene Citrate and Dexamethasone
Lead Sponsor:
San Antonio Military Medical Center
Conditions:
Infertility
Eligibility:
FEMALE
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine if the addition of dexamethasone to clomiphene citrate will increase the pregnancy rate of intrauterine insemination (IUI) cycles.
Detailed Description
For decades clomiphene citrate (CC) has been the first line therapy for ovulation induction in anovulatory or oligoovulatory women, and for superovulation in women with unexplained infertility or part...
Eligibility Criteria
Inclusion
- Active duty military members or dependents seeking infertility treatment at Brooke Army Medical Center
- primary or secondary infertility
- candidate for intrauterine insemination (IUI)
Exclusion
- Severe male factor infertility (total motile sperm count \<10 million/mL)
- Bilateral fallopian tube obstruction
- Diminished ovarian reserve (baseline follicle stimulating hormone \> 20)
- History of clomiphene resistance as determined by a Clomid challenge test or prior non-ovulatory cycles while taking clomiphene
- Known or suspected hypopituitarism or hypothalamic amenorrhea
- Six or more prior therapeutic CC cycles without a pregnancy
- Diabetes
- Renal impairment, hepatitis, hepatic cirrhosis, or myasthenia gravis
- Osteoporosis
- Cataracts or glaucoma
- Congenital Adrenal Hyperplasia, Cushing's disease, or any condition requiring chronic corticosteroid use
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2015
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT01856062
Start Date
May 1 2013
End Date
June 1 2015
Last Update
February 28 2014
Active Locations (1)
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1
San Antonio Military Medical Center
Fort Sam Houston, Texas, United States, 78234