Status:
COMPLETED
Ventricular Arrhythmias in Uremic Cardiomyopathy
Lead Sponsor:
Northwell Health
Collaborating Sponsors:
Icahn School of Medicine at Mount Sinai
Conditions:
Cardiomyopathy
Eligibility:
All Genders
18+ years
Brief Summary
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue. When active this gene builds a crucial p...
Detailed Description
This study will test the hypothesis that patients with uremic cardiomyopathy have reduced levels of SERCA2a protein compared to those with normal kidney function. We propose that such a correlation wi...
Eligibility Criteria
Inclusion
- age 18 years or older
- Patients with stage 5 CKD or ESRD and those with normal CKD will be considered as possible candidates if admitted for one of the following vascular procedures
- coronary artery bypass grafting, or vascular bypass surgery, or arteriovenous fistula creation, or arteriovenous graft surgery.
- The aforementioned patients will be included if they have LVH or diastolic dysfunction and a normal LVEF on echocardiogram within one year of their scheduled surgery.
Exclusion
- Age less than 18 ;
- Pregnancy;
- Dilated cardiomyopathy;
- left ventricular ejection fraction (LVEF) less than or equal to 50%;
- Patients on digoxin.
- antiarrhytmic medications;
- baseline electrolyte abnormalities;
- Atrial fibrillation;
- Bundle branch block
Key Trial Info
Start Date :
January 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01856400
Start Date
January 1 2010
End Date
August 1 2013
Last Update
February 3 2014
Active Locations (1)
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1
Staten Island University Hospital
Staten Island, New York, United States, 10305