Status:
COMPLETED
Safety of Nasal Influenza Immunisation in Egg Allergic Children
Lead Sponsor:
University Hospital Southampton NHS Foundation Trust
Collaborating Sponsors:
Imperial College London
Public Health England
Conditions:
Egg Hypersensitivity
Eligibility:
All Genders
2-17 years
Brief Summary
Egg allergy is common in early childhood, affecting at least one in 50 preschool children. Influenza ("'flu") vaccines contain egg protein, as the vaccine is cultured in hen's eggs. There is robust da...
Eligibility Criteria
Inclusion
- Aged 2 - 17 years old
- Physician-diagnosis of egg allergy
Exclusion
- Contraindicated as acutely unwell or current unstable asthma
- Use of asthma reliever medication in last 72 hours
- Recent administration of a medication containing antihistamine within the last 4 days
- Current oral steroid for asthma exacerbation or course completed within last 2 weeks
- Contraindications to ingredient in LAIV (notwithstanding allergy to egg protein)
- Previous allergic reaction to an influenza vaccine
- Children and adolescents who are clinically immunodeficient due to conditions or immunosuppressive therapy such as: acute and chronic leukaemias; lymphoma; symptomatic HIV infection; cellular immune deficiencies; and high-dose corticosteroids.
- Children and adolescents younger than 18 years of age receiving salicylate therapy because of the association of Reye's syndrome with salicylates and wild-type influenza infection.
Key Trial Info
Start Date :
September 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2014
Estimated Enrollment :
282 Patients enrolled
Trial Details
Trial ID
NCT01859039
Start Date
September 1 2013
End Date
February 1 2014
Last Update
August 10 2020
Active Locations (12)
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1
Sandwell General Hospital
Birmingham, United Kingdom
2
Bristol Royal Hospital for Children
Bristol, United Kingdom
3
Royal Hospital for Sick Children
Edinburgh, United Kingdom
4
Leicester Royal Infirmary
Leicester, United Kingdom