Status:
COMPLETED
Effects of Aerobic Exercise in Patients With Pre-diabetes
Lead Sponsor:
Baystate Medical Center
Conditions:
Prediabetes
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
It is well known that diabetes and excessive or high blood sugars causes blood vessel and blood cell damage. It is also possible, then, that people with pre-diabetes may also start to have blood vesse...
Detailed Description
* To refine a non-invasive test for endothelial dysfunction. The investigators will examine the flow response to sheer-stress induced by the relief of pressure exerted with a blood pressure cuff on th...
Eligibility Criteria
Inclusion
- Prediabetic
- Impaired fasting glucose (100-125mg/dl)
- Impaired glucose tolerance (2' post between 140-199mg/dl)
- HbA1C 5.7-6.4 mg/d (inclusive)
- Exercise Naive
- BMI between 20-39.9
- Nutritional Counseling prior to participation with CDE/RD
- Willing to wear activity monitor
- Willing to keep a dietary log
Exclusion
- Pace maker or other implanted device that might have interference with Tanita scale
- Any contraindication to moderate exercise
- Previous coronary disease or cerebrovascular event active or clinically significant coronary vascular disease, or peripheral vascular disease
- Diabetes
- Uncontrolled hypertension (SBP \> 140 or DBP \> 90 on 3 separate occasions) ACE's or ARB's
- Premature familial CAD (Father \< 55years\_\_\_\_ Mother \<65years)
- HDL \< 40mg/dl
- Triglycerides \>400mg/dl
- Any new lipid lowering medication started in the past 6 months
- Framingham Risk Score two or more
- Smoking
- Hypertension (B/P \> 140/90 or on antihypertensives)
- HDL \< 40mg/dl
- Age men \>45years or women \>55years
- Low hematocrit ( or hemoglobinopathies that may impair exercise tolerance) or abnormal CBC
- Uncontrolled hypo/hyperthyroidism
- Active smoking
- Liver disease ( alt or AST\> 2.5's UNL)
- Moderate or Severe Kidney disease, current or history
- Pancreatitis, current or history
- Any medication started in the last 3 months
- Active non healing wounds
- Recent Surgery in the last 3 months
- Anti-inflammatory disease, current or history
- Regular use of anti-inflammatory drugs
- CA
- Alcoholism
- Women who are pregnant or intending to become pregnant
- Oral or Injectable antidiabetic medication
- Post menopausal women on hormone replacement
- Any steroid medication (oral, inhaled, injected or nasal)
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2013
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01860599
Start Date
March 1 2010
End Date
May 1 2013
Last Update
July 17 2014
Active Locations (1)
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1
Baystate Medical Center
Springfield, Massachusetts, United States, 01199