Status:
UNKNOWN
Neurococognitive and Functioal Assessment of Patients With Brain Metastases
Lead Sponsor:
Thomas Jefferson University
Conditions:
Cerebral Metastases Patients
Eligibility:
All Genders
18-70 years
Brief Summary
The investigators seek to perform an observational study in patients with brain metastases that are to undergo whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS) treatment in orde...
Detailed Description
This research protocol is designed to perform neuropsychological testing and fMRI scanning in patients with brain metastases that are to undergo either WBRT or SRS treatment at Thomas Jefferson Univer...
Eligibility Criteria
Inclusion
- Patients with a cumulative intracranial disease burden of up to but not exceeding 8cc.
- Patients with newly diagnosed brain metastases are undergoing WBRT or SRS as previously determined by their oncologist and or radiation oncologist.
- Right or left hand dominance.
- Karnofsky performance status (KPS) equal to or greater than 70.
- 70 years old or younger.
- All non-hematopoietic histologies except melanoma and renal cell carcinoma.
- Brainstem lesions are acceptable.
- Normal renal function to tolerate a contrast enhanced MRI scan.
- Patients must provide study specific informed consent prior to study entry.
Exclusion
- Age less than 18 years old.
- KPS \<70.
- Pregnant female.
- Active systemic disease.
- Age greater than 70 years old.
- Patients with leptomeningeal metastases.
- Contraindication for MRI such as implanted metal devices, foreign bodies or severe claustrophobia or axial back pain precluding a prolonged MRI study.
- Prior radiation therapy to the brain.
- Poor renal function rendering contrast enhanced MRI un-obtainable.
- Histological diagnosis of small cell lung cancer.
- Craniotomy or other major surgery within 2 weeks of start of either SRS or WBRT.
Key Trial Info
Start Date :
March 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01861405
Start Date
March 1 2013
Last Update
December 18 2014
Active Locations (1)
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1
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107