Status:
COMPLETED
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Granulomatosis With Polyangiitis
Eligibility:
All Genders
18+ years
Brief Summary
Anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis are rare diseases characterized by inflammation of blood vessels. Among the numerous cell types that play a role in vasculitis, one of...
Detailed Description
A - Specific Aims General aim: This project is designed to study physiopathological mechanisms involved in GPA at the cellular and molecular level. the investigators want to study neutrophils as progn...
Eligibility Criteria
Inclusion
- For patients with GPA
- Systemic or localized GPA with ACR (American College of Rheumatology) criteria.
- BVAS \> 3.
- ANCA anti-PR3 or anti-MPO
- Consent form signed
- For patients with MPA
- Systemic MPA with Chapel Hill criteria.
- BVAS \> 3.
- ANCA anti-MPO
- Consent form signed
- For patients with EGPA
- Systemic EGPA with ACR (American College of Rheumatology) criteria.
- BVAS \> 3.
- ANCA anti-PR3 or anti-MPO
- Consent form signed
- For atherosclerotic patients
- Ischemic stroke
- Coronary heart attack
- Peripheral vascular disease responsible for intermittent claudication
- Carotid Stenosis
Exclusion
- Pregnancy
- \<18 yr
- Malignancy
- Infectious diseases: HIV, HBV, HCV
Key Trial Info
Start Date :
May 25 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 18 2018
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT01862068
Start Date
May 25 2012
End Date
May 18 2018
Last Update
September 12 2025
Active Locations (1)
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1
Cochin Hospital
Paris, France, 75014