Status:
COMPLETED
Mechanisms of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Intradialytic Hypertension
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is 1) to determine what physiologic factors (extracellular fluid overload or vasoconstriction) contribute more to increased blood pressure levels between dialysis treatments ...
Eligibility Criteria
Inclusion
- Inclusion Criteria (for Aims 1 and 2):
- age more than 18 years
- Hypertension defined as systolic blood pressure more than 140 mmHg before dialysis or more than 130 mmHg after dialysis
- For case subjects with intradialytic hypertension: systolic blood pressure increase more than 10 mmHg from pre to post dialysis in at least 4 out of 6 screening treatments
- For control subjects: systolic blood pressure decrease more than 10 mmHg from pre to post dialysis in at least 4 out of 6 screening treatments
- Inclusion criteria for Aim 3 includes the case subjects described above.
- Exclusion Criteria:
- For Aims 1 and 2:
- Hemodialysis vintage less than 1 month
- Amputated arm or leg
- Presence of cardiac defibrillator or pacemaker
- Presence of large metal prosthesis
- Failure to achieve dry weight
- For Case subjects participating in Aim 3:
- Patients with a specific indication for beta blocker therapy including systolic heart failure, history of myocardial infarction, history of tachyarrhythmia or angina being managed with beta blocker therapy.
- Patients with contraindications to beta blockade including bradycardia (heart rate less than 60 beats per minute) while not on a pulse lowering drug, severe reactive airway disease, prior intolerance to beta blocker therapy
- Prior intolerance to alpha blocker therapy
Exclusion
Key Trial Info
Start Date :
January 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2018
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT01862497
Start Date
January 1 2013
End Date
April 1 2018
Last Update
May 1 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75390