Status:
UNKNOWN
Recognition and Early Intervention on Prodrome in Bipolar Disorders
Lead Sponsor:
Guangzhou Psychiatric Hospital
Collaborating Sponsors:
The University of Hong Kong
Conditions:
Bipolar Disorder
Eligibility:
All Genders
10-25 years
Phase:
NA
Brief Summary
Background and study hypothesis: Many studies including prospective studies have been demonstrated that a long symptomatic prodromal phase exists prior to the onset of full-brown bipolar disorder, la...
Detailed Description
Background and study hypothesis: Bipolar disorder is one of the most common recurrent mental illnesses, with a lifetime prevalence of 3.9%, causing physical as well as mental disabilities. Nearly 40%...
Eligibility Criteria
Inclusion
- have at least one biological parent diagnosed as bipolar disorder (bipolar I or II)
- have at least one of the following syndromes i) two or more DSM-IV defined hypomania/mania symptoms, lasting for at least 4 days; ii) two or more DSM defined major depressive symptoms, lasting for 1 week; iii) at least one of the psychotic symptoms, lasting at least 10 min for each manifestation, and 2-7 manifestations a week for at least 3 months, including: ideas of reference; odd ideas, odd belief, unusual perceptual experiences, bizarre thought or speech, Grandiosity, suspicious ideas, paranoid idea, odd mannerisms, hallucination, disorganized/catatonic behavior; iv)two or more of the DSM-IV defined Attention deficit hyperactivity disorder (ADHD)symptoms; and there must be clear evidence of clinically significant impairment in social, academic, or occupational functioning due to ADHD symptoms
Exclusion
- DSM-IV defined Axis I disorders;
- Serious general medical illness;
- mental retardation;
- was/is treated with antipsychotic drugs;
- unable to complete neuropsychological tests due to physical conditions;
- in pregnancy and lactation;
- was taking thyroxine therapy in the last three months or is taking hormone therapy
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01863628
Start Date
March 1 2013
End Date
December 1 2015
Last Update
March 17 2015
Active Locations (2)
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1
Guangzhou Psychiatric Hospital
Guangzhou, Guangdong, China, 510370
2
Guangzhou psychiatric Hospital
Guangzhou, Guangdong, China, 510370