Status:
COMPLETED
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
Lead Sponsor:
Harvard School of Public Health (HSPH)
Collaborating Sponsors:
University of Toronto
Unity Health Toronto
Conditions:
Heart Rate
Heart Rate Variability
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air ...
Detailed Description
Air pollution is a pervasive environmental threat estimated to cause \~800,000 deaths every year worldwide, mostly due to cardiovascular disease. This proposal addresses a fundamental mechanistic and ...
Eligibility Criteria
Inclusion
- Healthy volunteer
- Age 18-60 years old
- Non-smoker
- must be able to fast 8 hours prior to exposure visits and for a further 4 hours during the exposure
Exclusion
- Subjects must not be regularly taking multivitamins, vitamins C \& E, folate, medications, fish oil or aspirin, oral or inhaled steroids, for 4 weeks before and during the trial.
- Lipid abnormalities
- Asthma or respiratory disease
- Hypertension (Bp\> 140/90) or taking any blood pressure drug
- Known cardiac disease
- abnormal homocysteine or glucose levels
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01864824
Start Date
June 1 2013
End Date
July 1 2014
Last Update
May 11 2017
Active Locations (1)
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1
Gage Occupational and Environmental Health St. Michael's Hospital/University of Toronto
Toronto, Ontario, Canada, M5T 1R4